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Mangosteen and Cancer Treatment

Cancer is one of the most fatal diseases in the world today. Millions of people have it but medical science has yet to figure out how to treat this terminal illness. A lot of concoctions and purported treatment protocols have come out in the market claiming they can cure cancer. However, it is the mangosteen that stood out from all the products believed to hold the key in the prevention and treatment of cancer.  Is this pure hype and anything more than wishful thinking or is there really a truth to this?

Mangosteen's Anti-Cancer Properties

Various studies and researches have shown that the phytoceuticals in mangosteen, particularly the xanthones exhibit some remarkable properties such as the ability to shrink tumors, prevent the proliferation or metastasis of cancer cells and the ability to trigger programmed cell death (apoptosis) for certain types of cancer. Other notable biologic activities include antibacterial, antifungal, antiviral, anti-inflammatory and antioxidant. If you are an oncologist or a cancer patient, you’ll find that this is quite an impressive list and probably the reasons why mangosteen has received much acclaim in the fight against cancer.

Xanthones, the major components of mangosteen, have been implicated in its anti-cancer effects. To date, scientists have discovered more than 40 different types of xanthones in mangosteen. However, a number of these necessitate further research in terms of structure and related medicinal properties. Among the more notable types of xanthones found in mangosteen are alpha-Mangostin, beta-Mangostin, 3-Isomangostin, Mangostanol, Gertanin, Garcinone A, Garcinone B, Garcinone C, Garcinone D, Garcinone E and Maclurin. The antioxidant properties that xanthones provide enabled mangosteen to rank very high in a new laboratory procedure called
Oxygen Radical Absorbance Capacity or ORAC. It has been revealed that mangosteen has 20 to 30 times the ability to absorb harmful free radicals when compared to most fruits and vegetables.

The highly potent antioxidant and cytotoxic properties of mangosteen are among the cornerstones in its ability to fight off cancer cells. Note that free radicals can cause damage to the body on the cellular level. They are capable of damaging genetic material (DNA) which can alter normal cell functions and replication, leading to the proliferation of aberrant cells that ultimately become tumors.  Xanthones are among nature’s most powerful antioxidants and they can easily rid the body of free radicals that can wreak havoc in human DNA, thereby minimizing the risk of developing cancer. In addition, the antibacterial and antiviral properties of mangosteen also contribute to the protection of genetic material as certain strains of bacteria and viruses are known to cause malignancy.

Apart, from xanthones, mangosteen also contains other beneficial substances like essential vitamins, minerals, and enzymes like catechins and polyphenols. They can all help in ensuring the wellness of cancer patients by providing the body with the substances needed to strengthen the immune system, specifically anti-cancer cells. Finally, compounds found abundantly in mangosteen can inhibit cyclooxygenase enzymes (COX 1 and COX 2), and can also induce programmed cell death (apoptosis) in cancer cells. Induction of apoptosis refers to the process of cell death wherein a
poptotic cells break into smaller fragments called apoptotic bodies that release chemicals that can be tracked by antibodies and other cells of the immune system so they can be phagocytized. As for tumors, the induction of apoptosis generally results in the repression of their growth and the reduction of their sizes.
There are literally hundreds of in vitro studies that can be found in the annals of medicine about the amazing health benefits and medicinal properties of mangosteen. A number of these relate to the ever elusive cure for cancer. While many of the findings require further tests and analysis, the bottom line is that all of them point to the single notion that mangosteen indeed has the potential to serve as anti-cancer agents for the chemotherapy of cancer.

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